Which drug produces a disulfiram-like (antabuse) reaction when alcohol is consumed______________?
Show answer Hide answer
Answer: C. Metronidazole
Explanation
Metronidazole inhibits aldehyde dehydrogenase, causing toxic acetaldehyde accumulation when alcohol is consumed. Blocking this crucial metabolic enzyme mirrors the exact mechanism of disulfiram intoxication therapy. Patients experience severe flushing, vomiting, and tachycardia due to un-metabolized acetaldehyde buildup. Aldehyde dehydrogenase is responsible for breaking down acetaldehyde into harmless acetic acid derivatives. Disulfiram-like reactions create extremely unpleasant physiological deterrents against concurrent alcohol consumption. Metronidazole is a widely prescribed antimicrobial targeting anaerobic bacterial and protozoal infections.
Patients receiving metronidazole must receive strict warnings to avoid alcohol in all forms. Accidental alcohol ingestion from cough syrups can trigger severe adverse disulfiram-like reactions. Pharmacists play a key role in counseling patients about dangerous drug and alcohol interactions. Penicillin G does not inhibit aldehyde dehydrogenase or cause adverse reactions with alcohol consumption. Clindamycin targets bacterial protein synthesis without producing disulfiram-like adverse metabolic effects. Doxycycline is a broad-spectrum tetracycline antibiotic that lacks alcohol-induced acetaldehyde accumulation properties.
Related questions
Q1. The pioneering dentist who initially employed Nitrous oxide for pain relief during dental extractions was_____________?
Show answer Hide answer
Answer: C. Horace wells
Horace Wells was a visionary American dentist who recognized the anesthetic properties of gases. He successfully demonstrated nitrous oxide anesthesia during his own dental extraction procedure. This historic milestone r...
Q2. The medication of choice for treating infections driven by non-penicillinase-producing staphylococci is___________?
Show answer Hide answer
Answer: C. Penicilling G
Penicillin G is exceptionally potent against non-penicillinase-producing staphylococcal strains. Sensitive bacteria lack the protective beta-lactamase enzymes that hydrolyze the antibiotic. The drug disrupts bacterial ce...
Q3. Identify the pharmaceutical agent that activates plasma antithrombin-III to exert its anticoagulant effects____________?
Show answer Hide answer
Answer: C. Heparin
Heparin binds directly to circulating plasma antithrombin-III molecules to change their conformation. This conformational change accelerates the inactivation of clotting factors like thrombin. Rapid anticoagulation preve...
Q4. Stepwise mutation leading to drug resistance is typically observed with_____________?
Show answer Hide answer
Answer: A. Penicillin
Streptomycin is well known for developing bacterial resistance via a single-step mutation mechanism, unlike penicillin.
Q5. A drug that binds to a receptor site and triggers the intrinsic functional activity of that receptor or enzyme system is designated as____________?
Show answer Hide answer
Answer: A. An agonist
An agonist is a specialized pharmacological agent that binds to specific cellular receptors. This binding action triggers the intrinsic functional activity and downstream signaling of the receptor. Cellular responses are...
Q6. The following pharmaceutical agents are beneficial in managing hypertension except_____________?
Show answer Hide answer
Answer: D. Pentoxifyline
Pentoxifylline is a hemorrheologic agent designed to improve erythrocyte flexibility. It decreases blood viscosity and enhances microcirculatory blood flow in ischemic tissues. It possesses no significant blood pressure...