In lichen planus, shrunken basal cells displaying eosinophilic cytoplasm along with pyknotic and fragmented nuclei are designated as__________?
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Answer: B. Civatte bodies
Explanation
Civatte bodies are apoptotic keratinocytes found in the lower epithelium, commonly observed in lichen planus. Shrunken basal cells displaying eosinophilic cytoplasm and pyknotic nuclei define these characteristic colloid bodies. Immunological attacks target basal epithelial cells, inducing apoptosis and forming these distinct microscopic structures. Apoptosis represents programmed cell death characterized by nuclear fragmentation and cytoplasmic condensation. Civatte bodies are also frequently identified in histopathological evaluations of lupus erythematosus skin lesions. The chronic inflammatory infiltrate underlying the epithelium drives basal cell damage in lichen planus.
Pathologists search for Civatte bodies when analyzing mucosal biopsy specimens for lichenoid reactions. Understanding microscopic cellular pathology helps confirm clinical suspicions of complex autoimmune disorders. Recognizing apoptotic bodies aids in differentiating immune-mediated mucoceless conditions from epithelial dysplasias. Tzanck cells are multinucleated acantholytic cells found in smears of herpesvirus or pemphigus vulgaris. Donovan bodies are intracellular bacteria diagnostic of the chronic sexually transmitted infection granuloma inguinale. Rushton bodies are calcified hyaline bodies found within the epithelial linings of odontogenic jaw cysts.
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