Albumin synthesis takes place in_____________?
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Answer: A. Liver
Explanation
Albumin is synthesized exclusively by specialized hepatocytes located within the parenchymal tissue of the liver. Once synthesized, liver cells secrete albumin directly into the bloodstream where it circulates throughout the body. The liver produces large quantities of albumin daily to maintain plasma oncotic pressure and transport ligands. Albumin is the most abundant protein found in human blood plasma, accounting for more than half of total serum protein. Hepatocytes possess extensive rough endoplasmic reticulum and Golgi apparatus machinery dedicated to high-rate plasma protein synthesis. Liver disease or cirrhosis significantly impairs albumin production, leading to fluid retention and peripheral edema.
The kidney filters blood and produces urine but does not synthesize major plasma proteins like albumin. Muscle tissue synthesizes structural proteins such as actin and myosin rather than circulating plasma albumin. The spleen functions as a lymphoid organ for immune defense and red blood cell filtration, not plasma protein synthesis.
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