The primary pharmacokinetic advantage that penicillin V holds over penicillin G is____________?
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Answer: A. More reliable oral obsorption
Explanation
Penicillin V possesses a chemical structure that resists degradation by gastric acid. This acid stability allows the drug to pass into the intestine for reliable absorption. Penicillin G is destroyed by acid, making oral dosing erratic and ineffective. Acid stability is a critical pharmacological property for oral drug administration. Gastric hydrochloric acid hydrolyzes unstable beta-lactam rings before absorption occurs. Improving oral bioavailability enhances patient convenience and outpatient treatment compliance.
Outpatients with mild infections receive oral penicillin V rather than injections. Injectable penicillin G remains reserved for serious infections requiring high blood levels. Pharmacokinetic comparisons guide clinicians in selecting appropriate administration routes. Greater resistance to penicillinase is a feature of penicillinase-resistant penicillins. Slower renal excretion is achieved using probenecid rather than structural changes in V. Broader antibacterial spectrum is not provided by penicillin V compared to penicillin G.
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