Oropharyngeal and esophageal candidiasis resulting from prolonged broad-spectrum antibiotic regimens is best managed using____________?
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Answer: C. Fluconazole
Explanation
Fluconazole is a reliable triazole antifungal agent administered orally or intravenously. It achieves high therapeutic concentrations in mucosal tissues affected by fungal overgrowth. Systemic absorption makes it exceptionally effective for treating oral and esophageal candidiasis. Broad-spectrum antibiotics eliminate normal bacterial flora, allowing opportunistic Candida to proliferate. Oropharyngeal candidiasis presents as painful white plaques on mucosal surfaces. Triazole antifungals inhibit fungal cytochrome P450 dependent lanosterol demethylase enzymes.
Immunocompromised patients frequently require prophylactic or therapeutic antifungal medications. Swishing and swallowing topical agents may fail in extensive esophageal fungal infections. Systemic azole therapy provides reliable clinical cure rates for mucosal yeast infections. Griseofulvin is used primarily for dermatophyte infections of skin, hair, and nails. Amphotericin is typically reserved for severe systemic fungal infections due to toxicity. Sulfonates are antibacterial agents that lack efficacy against fungal pathogen species.
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Answer: C. Drug safety
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