The greatest amount of glucose absorption takes place in_______________?
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Answer: A. PCT
Explanation
Virtually all filtered glucose is actively reabsorbed via sodium-glucose cotransporters in the proximal convoluted tubule. The proximal tubule possesses specialized transport proteins that ensure high capacity glucose reclamation from the filtrate. This prevents glucose from being lost in the urine under normal physiological conditions. The kidneys filter large amounts of glucose daily through the glomerulus into the renal tubule system. Sodium-glucose linked transporters use the sodium concentration gradient to move glucose across the apical membrane. Once inside the epithelial cell glucose exits across the basolateral membrane into peritubular capillaries via facilitated diffusion.
The distal convoluted tubule is primarily involved in fine-tuning ion balance rather than massive glucose absorption. The loop of Henle focuses mainly on establishing medullary osmotic gradients and reabsorbing water and salts. Stating none is incorrect because the proximal convoluted tubule is the primary site for glucose uptake.
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