Oral hairy leukoplakia frequently manifests in individuals with AIDS, most commonly appearing at the site of_______________?
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Answer: A. Lateral borders of tongue
Explanation
Oral hairy leukoplakia appears as white plaques classically located on the lateral borders of the tongue. Immunocompromised patients frequently harbor Epstein-Barr virus reactivation in epithelial cells at this specific site. The lateral tongue provides an ideal microenvironment for the characteristic corrugated epithelial proliferation to develop. The condition is caused by opportunistic reactivation of the Epstein-Barr virus in the oral mucosal epithelium. Clinically, the lesions present as adherent white vertical folds or corrugated plaques that cannot be wiped off. It serves as a significant clinical indicator of declining immune function in HIV-positive patients.
Sublingual mucosa is rarely the primary site for hairy leukoplakia, which heavily favors the tongue borders. The soft palate is a common site for viral enanthemas or Kaposi sarcoma rather than corrugated hairy leukoplakia. Buccal mucosa frequently shows frictional keratosis or lichenoid lesions rather than the characteristic lateral tongue plaques.
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