All of the following factors facilitate tissue wound healing except_________?
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Answer: B. Steroids
Explanation
Corticosteroids inhibit inflammation, collagen synthesis, and immune responses, thereby hindering tissue wound healing. Successful wound repair relies on an adequate initial inflammatory phase to clear debris and recruit fibroblasts. Steroid medications suppress the proliferative and remodeling phases necessary for strong scar tissue formation. Protein synthesis provides essential amino acids required for cellular proliferation and extracellular matrix deposition. Vitamin C acts as a crucial cofactor for proline and lysine hydroxylation during collagen molecule stabilization. Adequate oxygen supply supports high metabolic demands of repairing tissues and prevents localized wound infections.
Patients on chronic systemic corticosteroid therapy often experience delayed wound healing and increased dehiscence rates. Surgical patients are evaluated for nutritional deficiencies to ensure optimal healing conditions post-operation. Hyperbaric oxygen therapy is sometimes utilized clinically to enhance healing in compromised chronic wounds. Option A is incorrect because dietary protein is necessary for supplying building blocks during tissue repair. Option C is wrong because vitamin C promotes proper collagen cross-linking essential for wound strength. Option D is incorrect because adequate oxygen perfusion is required for fibroblast proliferation and collagen synthesis.
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