Which specific syndrome features an esophageal web accompanied by dysphagia, oral mucosal atrophy, and microcytic hypochromic anemia_____________?
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Answer: B. Plummer-vinson
Explanation
Plummer-Vinson syndrome uniquely combines esophageal webs with iron-deficiency anemia. Patients suffer from painful dysphagia due to mucosal atrophy in the upper esophagus. The classic triad directly links these specific hematological and gastrointestinal clinical findings. The condition is primarily diagnosed in middle-aged women experiencing chronic iron deficiency. Esophageal webs are thin mucosal folds protruding into the lumen of the esophagus. Proper management involves iron supplementation and mechanical dilation of the esophageal stricture.
This syndrome significantly increases the long-term risk of developing upper gastrointestinal squamous cell carcinomas. Clinicians must evaluate patients presenting with unexplained iron-deficiency anemia for hidden webs. Early detection helps prevent severe nutritional deficiencies and improves patient swallowing function. Marfan syndrome is a genetic connective tissue disorder affecting the skeletal and cardiovascular systems. Meckel syndrome is a lethal developmental ciliopathy characterized by multiple congenital malformations. Sjogren syndrome is an autoimmune disease targeting exocrine glands and causing severe dry mouth.
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