Which pharmaceutical agent is prescribed to counteract gastric irritation caused by NSAID therapy_______________?
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Answer: D. Misoprostol
Explanation
Misoprostol is a synthetic prostaglandin E1 analog that protects gastric mucosa from NSAID damage. It inhibits gastric acid secretion while stimulating protective mucus and bicarbonate production. Replenishing depleted prostaglandins prevents ulcer formation caused by chronic anti-inflammatory drug therapy. Endogenous prostaglandins maintain gastric mucosal defense mechanisms by regulating blood flow and mucus. NSAIDs block prostaglandin synthesis, leaving the stomach lining vulnerable to acidic erosion and ulcers. Synthetic analogues replicate protective physiological functions directly within the gastrointestinal tract.
Patients requiring long-term NSAID therapy often take misoprostol or proton pump inhibitors concurrently. Prophylactic gastroprotection reduces the incidence of debilitating gastrointestinal bleeding complications. Understanding prostaglandin physiology allows clinicians to prevent predictable drug-induced adverse effects. Roxatidine is an H2 receptor antagonist reducing acid secretion rather than being a prostaglandin analog. Pirenzepine is an antimuscarinic agent affecting gastric secretions through different neural pathways. Betaxolol is a cardioselective beta-blocker used for hypertension and glaucoma management.
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