Which medication might be prescribed to manage rheumatoid arthritis in a patient with hemophilia ?
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Answer: A. Acetaminophen
Explanation
Acetaminophen is the preferred analgesic for patients with bleeding disorders or those taking anticoagulants. Unlike nonsteroidal anti-inflammatory drugs, acetaminophen does not impair platelet aggregation or function. It also spares the gastric mucosal lining, avoiding the risk of severe gastrointestinal bleeding. Hemophilia is an inherited bleeding disorder caused by a deficiency in crucial coagulation clotting factors. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase enzymes, which are vital for normal platelet plug formation. Analgesic selection must carefully balance pain relief efficacy against the patient's underlying bleeding risks.
Managing chronic arthritic pain in hemophiliac patients requires avoiding drugs that exacerbate bleeding tendencies. Acetaminophen provides safe pain relief when dosed correctly, though hepatotoxicity can occur with excess use. Healthcare providers must educate patients on medication safety to prevent accidental bleeding complications. Acetylsalicylic acid irreversibly inhibits platelets and severely exacerbates bleeding risks in hemophilia patients. Phenylbutazone is a potent nonsteroidal anti-inflammatory drug that significantly increases gastrointestinal bleeding risks. Naproxen inhibits cyclooxygenase enzymes, impairing platelet function and increasing bleeding tendencies in vulnerable patients.
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