The biosynthesis of collagen takes place inside the______________?
Show answer Hide answer
Answer: D. Fibroblasts
Explanation
Fibroblasts are specialized connective tissue cells that synthesize and secrete procollagen molecules into the extracellular space. Inside these cells, ribosomes translate messenger RNA to build polypeptide chains that form the classic triple-helix structure. Fibroblasts then package and export these precursor proteins so they can assemble into mature collagen fibers. Fibroblasts are widely distributed throughout the body in loose and dense connective tissues supporting various organs. Collagen biosynthesis requires intracellular hydroxylation steps that depend heavily on adequate vitamin C availability. Extracellular processing cleaves terminal peptides from procollagen to form insoluble tropocollagen molecules.
Fibroblast-mediated collagen biosynthesis is essential for normal wound healing and scar formation after injury. Deficiencies in collagen synthesis, such as in scurvy, lead to fragile connective tissues and poor wound repair. Periodontal tissues rely on continuous fibroblast activity to maintain the density of supporting ligament fibers. Chondroblasts are specialized cells that synthesize the extracellular matrix components specifically found in cartilage. Odontoblasts synthesize the unique organic matrix of dentin, which includes dentin phosphophoryn and collagen. Osteoblasts are responsible for synthesizing the organic osteoid matrix of bone tissue during skeletal remodeling.
Related questions
Q1. The most numerically abundant cells found in the dental pulp are______________?
Show answer Hide answer
Answer: B. Fibroblasts
Histological counts show that fibroblasts make up the vast majority of cells in dental pulp. These versatile connective tissue cells continuously produce extracellular matrix proteins and collagen fibers. Their high nume...
Q2. Cementum can be described by the fact that_____________?
Show answer Hide answer
Answer: C. Often overlaps the enamel
Variations at the cementoenamel junction frequently include cementum overlapping the cervical enamel. Histological examination reveals that cementum meets, gaps, or overlaps enamel at the cervical neck. Overlapping relat...
Q3. Dental lamina activity persists up until_______________?
Show answer Hide answer
Answer: D. 4 years
Dental lamina proliferation can occasionally remain active for up to four years after birth. Residual epithelial remnants can give rise to late-forming succedaneous or supernumerary teeth. Histological studies confirm th...
Q4. The dentinoenamel junction is characterized as_________________?
Show answer Hide answer
Answer: C. Scalloped and the convexities are directed towards dentin
The dentinoenamel junction exhibits a distinct scalloped contour with convexities oriented toward the dentin. This interlocking microscopic design significantly enhances the structural adhesion between enamel and dentin....
Q5. In which condition do dentinal tubules undergo calcification_______________?
Show answer Hide answer
Answer: A. Sclerotic dentin
Sclerotic dentin is characterized by the complete calcification and obliteration of dentinal tubules. Chronic stimuli prompt odontoblasts to deposit mineral crystals inside dentinal tubules, blocking their lumen. Transpa...
Q6. The dental papilla gives rise to the formation of_____________?
Show answer Hide answer
Answer: B. Pulp & Dentin
The ectomesenchymal dental papilla differentiates specifically to form both dental pulp and dentin. Odontoblasts derived from the dental papilla synthesize the dentin matrix surrounding the pulp. The central portion of t...