The amyloid protein subtype deposited in senile systemic amyloidosis is_________________?
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Answer: D. Transthyretin
Explanation
Senile systemic amyloidosis is characterized by the systemic deposition of misfolded wild-type transthyretin proteins. Transthyretin is a normal serum carrier protein that can aggregate into amyloid fibrils in elderly individuals. These protein deposits accumulate progressively in cardiac and other tissues, potentially leading to restrictive cardiomyopathy. Amyloidosis involves abnormal extracellular deposition of insoluble fibrillar proteins disrupting normal organ architecture. Transthyretin is synthesized primarily by the liver and transports thyroid hormones and retinol in blood. Senile systemic amyloidosis is a relatively common age-related condition predominantly affecting elderly cardiac muscle tissue.
Cardiologists evaluate older patients presenting with heart failure for potential transthyretin cardiac amyloidosis involvement. Advanced imaging techniques help identify transthyretin deposition without always requiring invasive endomyocardial biopsies. Recognizing age-related amyloidosis ensures elderly patients receive appropriate supportive care and symptom management. AL protein deposition is characteristic of primary amyloidosis associated with plasma cell dyscrasias instead. Beta-2 microglobulin accumulates in patients undergoing long-term hemodialysis rather than causing senile systemic amyloidosis. Alpha-amyloid protein is associated with neurodegenerative conditions like Alzheimer disease rather than systemic transthyretin amyloidosis.
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