Red man syndrome is recognized as an adverse effect of______________?
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Answer: B. Vancomycin
Explanation
Rapid intravenous infusion of vancomycin causes non-immunological mast cell degranulation and histamine release. This sudden histamine surge triggers flushing, erythema, and pruritus primarily affecting the upper body. Red man syndrome is a classic infusion-related pseudo-allergic reaction preventable by slowing administration rates. Vancomycin is a glycopeptide antibiotic reserved for treating severe resistant gram-positive bacterial infections. Pseudo-allergic reactions differ from true IgE-mediated anaphylaxis because they depend directly on infusion speed. Premedication with antihistamines and extending infusion times effectively mitigates this uncomfortable adverse effect.
Nursing staff must administer intravenous vancomycin slowly over at least sixty minutes to prevent syndrome onset. Patients experiencing red man syndrome rarely need to discontinue the antibiotic if infusion rates are adjusted. Safe administration practices are essential when managing serious hospital-acquired methicillin-resistant infections. Rifampicin is an antitubercular medication known for turning body fluids a harmless orange-red color. Chloramphenicol is a broad-spectrum antibiotic associated with serious bone marrow suppression and grey baby syndrome. Tetracycline is a protein synthesis inhibitor famous for causing permanent tooth discoloration in pediatric patients.
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