Leukoplakia lesions carrying the highest risk of malignant transformation are located on the_____________?
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Answer: A. Dorsum of tongue
Explanation
Leukoplakia lesions on the floor of the mouth carry high risks. The lateral border of the tongue also represents a high-risk site. Thin non-protective mucosal lining increases vulnerability to malignant transformation. Leukoplakia is a clinical term for a white plaque that cannot be scraped off. Biopsy is mandatory to grade epithelial dysplasia within high-risk lesions. Tobacco and alcohol use synergistically increase the risk of malignant conversion.
Surgical removal or laser ablation is often performed on dysplastic lesions. Regular clinical surveillance helps detect early squamous cell carcinomas. Patient education regarding cessation of tobacco use is crucial. Dorsum of the tongue has a lower malignant transformation risk than other sites. Buccal mucosa leukoplakia carries a relatively lower statistical risk. Palatal leukoplakia is often associated with reverse smoking and benign keratosis.
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