Large open wounds marked by tissue loss that heal via granulation tissue formation at the base are typical of______________?
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Answer: A. Secondary healing
Explanation
Large open wounds with significant tissue loss cannot be approximated cleanly by surgical sutures. Healing occurs by secondary intention through the development of a robust granulation tissue base. Wound contraction and epithelial migration gradually close the defect over an extended period. Primary healing occurs in clean surgical incisions with minimal tissue destruction and rapid closure. Secondary healing involves prolonged inflammation, abundant granulation, and subsequent scar formation. Myofibroblasts play a central role in contracting the wound edges together during secondary healing.
Chronic ulcers, severe burns, and infected lacerations typically heal via secondary intention. Medical practitioners manage open wounds carefully to prevent infection during granulation growth. Secondary healing results in larger fibrous scars compared to clean primary surgical closures. Primary healing requires clean, closely approximated wound edges rather than large tissue gaps. Cicatrisation refers to scar tissue formation rather than the overall process of secondary healing. Regeneration restores original parenchymal architecture, which differs from fibrotic secondary repair.
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