Identify the substance that acts as a betalactamase inhibitor_____________?
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Answer: B. Sulbactum
Explanation
Sulbactam is a permanent inhibitor of bacterial beta-lactamase enzymes produced by resistant pathogens. It binds competitively and irreversibly to these destructive enzymes to protect companion beta-lactam antibiotics. This combination restores the bactericidal efficacy of antibiotics against penicillin-resistant bacterial strains. Many bacteria develop resistance by secreting beta-lactamase enzymes that cleave the beta-lactam ring of antibiotics. Beta-lactamase inhibitors possess minimal intrinsic antibacterial activity but rescue vulnerable antibiotics from destruction. Common clinical formulations combine sulbactam with ampicillin for broad-spectrum empirical therapy.
Hospitals rely on beta-lactamase inhibitor combinations to treat stubborn intra-abdominal and respiratory infections. Infectious disease protocols mandate susceptibility testing to determine if inhibitor combinations are required. Pharmacological rescue of susceptible antibiotics extends the clinical utility of older penicillin derivatives. Ampicillin is a standard beta-lactam antibiotic that remains vulnerable to degradation by bacterial beta-lactamases. Cloxacillin is a penicillinase-resistant penicillin rather than a dedicated beta-lactamase inhibitor compound. Penicillin G is a classic beta-lactam antibiotic that is readily destroyed by bacterial beta-lactamase enzymes.
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