Chronic, long-term use of aspirin typically results in______________?
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Answer: D. A & B
Explanation
Chronic aspirin use suppresses protective gastric prostaglandin synthesis significantly. This mucosal vulnerability promotes the development of erosive gastritis and peptic ulcers. Simultaneously, impaired platelet aggregation leads to increased bleeding defects and hemorrhage. Prostaglandins stimulate bicarbonate and mucus secretion to shield gastric lining tissues. Inhibition of platelet cyclooxygenase prevents normal hemostatic plug formation after injury. Long-term systemic exposure compounds these gastrointestinal and hematological risks.
Patients on chronic antiplatelet therapy often require gastroprotective proton pump inhibitors. Clinicians evaluate bleeding risks carefully before prescribing long-term aspirin regimens. Gastrointestinal bleeding can lead to chronic iron deficiency anemia over time. Option A is incomplete because bleeding defects also occur frequently. Option B is incomplete since peptic ulcer formation is equally prominent. Option C carcinoma is not a direct consequence of long-term aspirin ingestion.
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