All of the following clinical findings are typical of Cushing's syndrome except_______________?
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Answer: C. Hypoglycemia
Explanation
Excess cortisol stimulates gluconeogenesis and peripheral insulin resistance, raising blood glucose levels. Cushing's syndrome typically presents with fasting hyperglycemia rather than decreased blood sugar. Option C is correct because hypoglycemia is not a characteristic clinical feature of this condition. Cushing's syndrome results from chronic exposure to excessive circulating glucocorticoid levels. Cortisol is a major stress hormone that mobilizes energy stores by breaking down tissues. Classic physical signs include central obesity, facial rounding, and purple abdominal striae.
Patients frequently develop secondary diabetes mellitus due to persistent glucocorticoid-induced insulin resistance. Endocrinologists perform specialized suppression tests to confirm hypercortisolemia in suspected cases. Recognizing metabolic symptoms is vital for early diagnosis and treatment of hormonal disorders. Truncal obesity is a hallmark physical manifestation of excess cortisol distribution in the body. Hypertension occurs frequently due to mineralocorticoid receptor activation and vascular reactivity changes. Poor wound healing stems from the potent anti-inflammatory and immunosuppressive actions of cortisol.
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